Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 87 Reviews
8.6
Supplement Facts
Serving Size: 2 Veg Capsules
Serving Per Container: 60
Amount Per Serving
%DV
BioCell Collagen® (Hydrolyzed Chicken Sternal Cartilage Extract) providing
1 g (1,000 mg)
**
Hydrolyzed Type II Collagen
570 mg
**
Chondroitin Sulfate
190 mg
**
Hyaluronic Acid
95 mg
**
Top Medical Research Studies
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
Most Useful Reviews
9
Significant joint relief
698 people found this helpful
I took collagen with Eicherb, and after the course, I noted significant improvements. My previous issues with joint pain, particularly knee discomfort, lessened considerably. After a month of taking this collagen, the pain in my knees decreased drastically, with some days completely pain-free. Should the pain return, it is not as severe as it was before.
Read More
9
Aching pain resolved
215 people found this helpful
The second type of collagen worked exceptionally well for my joint pain. I used to experience persistent aching in my knees, but after just a course of this collagen, the pain disappeared completely.
Read More
7.5
Pain improvement noted
118 people found this helpful
Collagen type 2 is beneficial for joint pain. I recommend taking it in cycles, with a break in between. Improvements were noticeable after a couple of weeks of taking it. I would advise anyone with joint discomfort, such as aching knees or hands, to try this type of collagen; it truly aids recovery.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
Read More
9
We explored the impact of high molecular weight sodium hyaluronate (HMW-HA) on pelvic pain caused by radiation-induced cystitis. In this prospective study involving 30 patients across seven centers in France, participants received six weekly intravesical instillations of HMW-HA.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Read More
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 87 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant joint relief
698 people found this helpful
I took collagen with Eicherb, and after the course, I noted significant improvements. My previous issues with joint pain, particularly knee discomfort, lessened considerably. After a month of taking this collagen, the pain in my knees decreased drastically, with some days completely pain-free. Should the pain return, it is not as severe as it was before.
Read More
9
Aching pain resolved
215 people found this helpful
The second type of collagen worked exceptionally well for my joint pain. I used to experience persistent aching in my knees, but after just a course of this collagen, the pain disappeared completely.
Read More
7.5
Pain improvement noted
118 people found this helpful
Collagen type 2 is beneficial for joint pain. I recommend taking it in cycles, with a break in between. Improvements were noticeable after a couple of weeks of taking it. I would advise anyone with joint discomfort, such as aching knees or hands, to try this type of collagen; it truly aids recovery.
Read More
9
No pain after weeks
57 people found this helpful
During training, my knees and shoulders ached significantly, hindering my squats. After taking this collagen for a few weeks alongside vitamin C, I experienced notable relief. After 1.5 months, I had completely forgotten why I started taking it. I highly recommend it as a genuine remedy.
Read More
9
Joints significantly improved
50 people found this helpful
This product is excellent for joint health. With regular use, my overall well-being and pain have improved considerably. Additionally, it benefits skin health, enhancing firmness and elasticity.
Read More
Frequently Asked Questions
7.5
Significant improvement
17 people found this helpful
My husband has suffered from constant pain in his right leg due to a lower spine issue for 1.5 years, and numerous treatments, including physiotherapy and painkillers, failed to help. After a recent consultation, a doctor recommended collagen, which we decided to try. Remarkably, within a week, he noticed improvement and stopped taking pain medication. He now takes 2 tablets twice a day alongside vitamin C for better absorption, and we plan to continue for the full three months. I only wish I had purchased one jar.
9
Knee pain relief
16 people found this helpful
This collagen has been a lifesaver for my knee! At my age, I've faced joint issues, but when my knee began to hurt significantly, I was lucky to have ordered this supplement based on a colleague's advice after a course of chondroitin. After just 2 days, the pain diminished greatly, and by day 5, it had completely resolved. Even my father, who has arthrosis at 60 years old, experienced relief within a week, which he initially found hard to believe. We will now continue taking it twice a year.
7.5
Effective for knees
14 people found this helpful
Wonderful! I began taking this in the autumn for my knee pain on an empty stomach, in conjunction with vitamin C. After 3 weeks, I felt a noticeable improvement. I highly recommend it!
9
Significant joint relief
698 people found this helpful
I took collagen with Eicherb, and after the course, I noted significant improvements. My previous issues with joint pain, particularly knee discomfort, lessened considerably. After a month of taking this collagen, the pain in my knees decreased drastically, with some days completely pain-free. Should the pain return, it is not as severe as it was before.
10
Knee pain free
5 people found this helpful
Wonderful! At 70 years old, I struggled with knee pain that prevented me from walking even a kilometre. On my doctor's advice, I began taking collagen type 2, and now I can climb five flights of stairs without the lift. I have completely forgotten the discomfort of knee pain. The quality of iHerb's products is very good.
9
No pain after weeks
57 people found this helpful
During training, my knees and shoulders ached significantly, hindering my squats. After taking this collagen for a few weeks alongside vitamin C, I experienced notable relief. After 1.5 months, I had completely forgotten why I started taking it. I highly recommend it as a genuine remedy.
7.5
Joint pain relief
12 people found this helpful
It's working! I've ordered a second can of this collagen. After being diagnosed with knee arthritis, I included collagen in my regimen alongside glucosamine and chondroitin. Remarkably, the pain has significantly reduced, allowing me to return to my exercise regimen, which brings me immense joy!
9
Effective combination
3 people found this helpful
I saw results when combining this with chondroitin and glucosamine from the same brand. The results are excellent; my joint pains are nearly absent, and climbing stairs has become much easier. I will definitely repeat the course.
9
Knee pain reduction
3 people found this helpful
I regularly take bovine collagen which somewhat helped my joint pain, but realised it mainly benefits the skin. So, I added type 2 collagen to my routine, and it truly seems to make a difference with my joints. The bovine collagen greatly diminished my knee pain, and coupling it with type 2 collagen and moderate exercise eliminated my remaining discomfort in mere days. It's a superb quality product for enhancing joint health.
7.5
Knee improvement noted
10 people found this helpful
This works for my knees! I have osteoarthritis in my right knee and shoulder. After 2 weeks of taking 2 pills twice daily, I felt improvements; my left knee pain disappeared entirely, while the right knee pain has reduced by 70%. Unfortunately, it hasn't helped my shoulder much, but I wholly recommend it for knee issues.
7.5
Pain improvement noted
118 people found this helpful
Collagen type 2 is beneficial for joint pain. I recommend taking it in cycles, with a break in between. Improvements were noticeable after a couple of weeks of taking it. I would advise anyone with joint discomfort, such as aching knees or hands, to try this type of collagen; it truly aids recovery.
We evaluated the effectiveness of adding hyaluronic acid and chondroitin sulfate to standard Bacillus Calmette-Guérin (BCG) treatment for bladder cancer.
In a multicentric study, patients receiving these instillations reported less pelvic pain, lower urinary frequency, and improved overall urinary symptoms compared to those who only had BCG.
This indicates that hyaluronic acid and chondroitin sulfate might offer significant relief, helping patients stick with their treatment plan and reducing the chances of therapy dropout.
In a multicentric study, patients receiving these instillations reported less pelvic pain, lower urinary frequency, and improved overall urinary symptoms compared to those who only had BCG.
This indicates that hyaluronic acid and chondroitin sulfate might offer significant relief, helping patients stick with their treatment plan and reducing the chances of therapy dropout.
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
4
We aimed to explore how hyaluronic acid-chondroitin sulfate treatment impacts pelvic pain in patients suffering from overactive bladder (OAB). Our study involved 150 newly diagnosed OAB patients split into three treatment groups: one receiving antimuscarinics, another with a combination of antimuscarinics and hyaluronic acid, and the third with no antimuscarinics. While combination therapy showed positive results for those new to antimuscarinics, only pelvic pain saw notable improvement in those who had stopped antimuscarinics. Unfortunately, we didn't see significant changes in incontinence or nocturia.
References
- Gubbiotti M, Rubilotta E, Bacchiani M, Cocci A, Rosadi S, et al. Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy. Int Urol Nephrol. 2025. doi:10.1007/s11255-025-04375-8
- Falabella R, Morra S, Milella L, LA Falce S, DI Fino G, et al. Overactive bladder: results from patients treated by hyaluronic acid-chondroitin sulphate therapy. Minerva Urol Nephrol. 2024. doi:10.23736/S2724-6051.24.05786-0
- Porcaro G, Laganà AS, Neri I, Aragona C. The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study. J Clin Med. 2024;13. doi:10.3390/jcm13030706
- Parente E, Colannino G, Bilotta G, Espinola MSB, Proietti S, et al. Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study. Clin Pract. 2023;13:1123. doi:10.3390/clinpract13050100
- Ghaith AF, Radwan MH, Rashed Taha M, Elbendary MA, Al Damhogy ME, et al. Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study. Arch Ital Urol Androl. 2022;94:447. doi:10.4081/aiua.2022.4.447
- Baboudjian M, Fourmarier M, Clement C, Cherasse A, Graziana JP, et al. Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study. World J Urol. 2022;40:141. doi:10.1007/s00345-021-03837-9
- Argüelles Rojas S, Oviedo Ortega JG, Velasco Sordo R. Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient. Cureus. 2021;13:e14549. doi:10.7759/cureus.14549
- Cai T, Gallelli L, Cione E, Verze P, Palmieri A, et al. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva Urol Nephrol. 2022;74:780. doi:10.23736/S2724-6051.21.04141-2
- Peng YC, Yueh-Hsia Chiu S, Feng M, Liang CC. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwan J Obstet Gynecol. 2020;59:922. doi:10.1016/j.tjog.2020.09.021
- Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, et al. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. J Obstet Gynaecol. 2021;41:263. doi:10.1080/01443615.2020.1755628
- Scarneciu I, Bungau S, Lupu AM, Scarneciu CC, Bratu OG, et al. Efficacy of instillation treatment with hyaluronic acid in relieving symptoms in patients with BPS/IC and uncomplicated recurrent urinary tract infections - Long-term results of a multicenter study. Eur J Pharm Sci. 2019;139:105067. doi:10.1016/j.ejps.2019.105067
- Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. doi:10.5152/tud.2018.63600
- Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, et al. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitis⁄painful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015;67:121.
- Huang W, Wang F, Wu C, Hu W. Efficacy and safety of pirarubicin combined with hyaluronic acid for non-muscle invasive bladder cancer after transurethral resection: a prospective, randomized study. Int Urol Nephrol. 2015;47:631. doi:10.1007/s11255-015-0940-1
- Kim A, Lim B, Song M, Choo MS. Pretreatment features to influence effectiveness of intravesical hyaluronic Acid instillation in refractory interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2014;18:163. doi:10.5213/inj.2014.18.3.163
- Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol. 2013;5:175. doi:10.1177/1756287213490052
